Version 5.4
Homo sapiens Gene: TNFRSF17
Summary
InnateDB Gene IDBG-15042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF17
Gene Name tumor necrosis factor receptor superfamily, member 17
Synonyms BCM; BCMA; CD269; TNFRSF13A
Species Homo sapiens
Ensembl Gene ENSG00000048462
Encoded Proteins
IDBP-15044
tumor necrosis factor receptor superfamily, member 17
IDBP-237384
tumor necrosis factor receptor superfamily, member 17
IDBP-747195
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:11965107-11968068
Strand Forward strand
Band p13.13
Transcripts
ENST00000053243 ENSP00000053243
ENST00000396495 ENSP00000379753
ENST00000562385 ENSP00000454314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
Biological Process
GO:0002376 immune system process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0033209 tumor necrosis factor-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022496
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 608
UniGene Hs.2556
RefSeq NM_001192
HUGO HGNC:11913
OMIM 109545
CCDS CCDS10552
HPRD 00144
IMGT
EMBL
GenPept
RNA Seq Atlas 608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca