InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp11b2

Summary

InnateDB Gene

IDBG-150454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp11b2

Gene Name

cytochrome P450, family 11, subfamily b, polypeptide 2

Synonyms

Cpn2; Cyp11b; Cyp11b-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022589

Encoded Proteins

IDBP-624070

cytochrome P450, family 11, subfamily b, polypeptide 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179142:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:74851010-74856318

Strand

Reverse strand

Band

Transcripts

ENSMUST00000167634

ENSMUSP00000131503

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004507	steroid 11-beta-monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0047783	corticosterone 18-monooxygenase activity

Biological Process

GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002017	regulation of blood volume by renal aldosterone
GO:0032342	aldosterone biosynthetic process
GO:0042756	drinking behavior
GO:0050801	ion homeostasis
GO:0055114	oxidation-reduction process