InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grb10

Summary

InnateDB Gene

IDBG-150690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grb10

Gene Name

growth factor receptor bound protein 10

Synonyms

5730571D09Rik; AI325020; Meg1; mKIAA0207

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020176

Encoded Proteins

IDBP-150694

growth factor receptor bound protein 10

IDBP-261929

growth factor receptor bound protein 10

IDBP-261931

growth factor receptor bound protein 10

IDBP-542785

growth factor receptor bound protein 10

IDBP-538957

growth factor receptor bound protein 10

IDBP-541358

growth factor receptor bound protein 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106070:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:11930508-12038683

Strand

Reverse strand

Band

Transcripts

ENSMUST00000093321	ENSMUSP00000091011
ENSMUST00000109654	ENSMUSP00000105281
ENSMUST00000109653	ENSMUSP00000105280
ENSMUST00000124587
ENSMUST00000148254
ENSMUST00000142877
ENSMUST00000143386	ENSMUSP00000118350
ENSMUST00000150972	ENSMUSP00000119344
ENSMUST00000143915	ENSMUSP00000115160

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868	response to insulin
GO:0042326	negative regulation of phosphorylation
GO:0042327	positive regulation of phosphorylation
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048009	insulin-like growth factor receptor signaling pathway