Version 5.4
Mus musculus Gene: Nt5c3
Summary
InnateDB Gene IDBG-150801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nt5c3
Gene Name 5'-nucleotidase, cytosolic III
Synonyms 1600024P05Rik; 2610206B05Rik; 3110004A18Rik; AI842776; cN-III; lupin; Nt5c3a; Nt5y; p36; PN-1; PN-I; PSN1; UMPH; Umph-1; Umph1
Species Mus musculus
Ensembl Gene ENSMUSG00000029780
Encoded Proteins
IDBP-150803
5'-nucleotidase, cytosolic III
IDBP-150805
5'-nucleotidase, cytosolic III
IDBP-789295
5'-nucleotidase, cytosolic III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122643:
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:56882400-56923932
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000101367 ENSMUSP00000098918
ENSMUST00000031793 ENSMUSP00000031793
ENSMUST00000152447 ENSMUSP00000138606
ENSMUST00000135558
ENSMUST00000126137
ENSMUST00000138647
ENSMUST00000134577
ENSMUST00000127725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
GO:0016740 transferase activity
GO:0016791 phosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation
GO:0046085 adenosine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122643
View Gene Order
ENSBTAG00000016709
Not yet available
Pathways
NETPATH
REACTOME
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00760
Nicotinate and nicotinamide metabolism pathway
mmu00240
Pyrimidine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00760
Nicotinate and nicotinamide metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.158936 Mm.487949
RefSeq NM_001252374 NM_026004 XM_006505272 XM_006505273 XM_006505275 XM_006505276
OMIM
CCDS CCDS20171 CCDS57424
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca