InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il12a

Summary

InnateDB Gene

IDBG-150825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12a

Gene Name

interleukin 12a

Synonyms

Il-12a; IL-12p35; Ll12a; p35

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027776

Encoded Proteins

IDBP-150827

interleukin 12a

IDBP-265868

interleukin 12a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22888135

Il12, consisting of Il12a and Il12b subunits, induces Il2ra to form high-affinity Il2 receptors on natural killer cells in response to mouse cytomegalovirus infection.

InnateDB Annotation from Orthologs

Summary

PMID 20935648

[Homo sapiens] IL12, consisting of IL12A and IL12B subunits, initiates local anti-tumour immunity by stimulating lymphoid tissue-inducer (LTi) cells bearing the natural cytotoxicity receptor NCR1 (NKp46).

PMID 22888135

[Homo sapiens] IL12, consisting of IL12A and IL12B subunits, induces IL2RA to form high-affinity IL2 receptors on natural killer cells in response to mouse cytomegalovirus infection. (Demonstrated in mouse)

PMID 23990628

[Homo sapiens] Macrophages cultured with bile acids produce lower levels of IL12 and display an anti-inflammatory phenotype characterized by an increased ratio of IL10 to IL12

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168811:
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:68690644-68698547

Strand

Forward strand

Band

Transcripts

ENSMUST00000029345	ENSMUSP00000029345
ENSMUST00000107816	ENSMUSP00000103446

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	3 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042163	interleukin-12 beta subunit binding
GO:0045513	interleukin-27 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0009615	response to virus
GO:0010224	response to UV-B
GO:0016477	cell migration
GO:0032496	response to lipopolysaccharide
GO:0032700	negative regulation of interleukin-17 production
GO:0032729	positive regulation of interferon-gamma production
GO:0032816	positive regulation of natural killer cell activation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042102	positive regulation of T cell proliferation
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832	defense response to protozoan
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050830	defense response to Gram-positive bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0097191	extrinsic apoptotic signaling pathway