Version 5.4
Mus musculus Gene: Relb
Summary
InnateDB Gene IDBG-151419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Relb
Gene Name avian reticuloendotheliosis viral (v-rel) oncogene related B
Synonyms shep
Species Mus musculus
Ensembl Gene ENSMUSG00000002983
Encoded Proteins
IDBP-151421
avian reticuloendotheliosis viral (v-rel) oncogene related B
IDBP-151423
avian reticuloendotheliosis viral (v-rel) oncogene related B
IDBP-151425
avian reticuloendotheliosis viral (v-rel) oncogene related B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21419662
Relb is required for Il17a production in T cell in response to bacterial infection. Relb deficient T cells resulted in a diminished innate immune response to E. coli infection.
PMID 25367573
Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
InnateDB Annotation from Orthologs
Summary
PMID 16951372
[Homo sapiens] RELB is a NF-kappaB subunit that participates in endotoxin tolerance by repressing pro-inflammatory gene expression.
PMID 17823304
[Homo sapiens] RELB mediates transcription of chemokines like IL8 via activation of AHR and Protein kinase A, and its expression is inhibited by Vitamin D3 analog in DCs.
PMID 12657634
[Homo sapiens] RELB acts as both transcription factor as well as a repressor of NF-kappaB gene expression by forming heterodimers with NFKB1 (p50 subunit) and NFKB2 (p100 subunit) or inhibiting RELA DNA binding activity, respectively.
PMID 19020113
[Homo sapiens] RELB sustains NFKBIA (IkappaB alpha) expression during endotoxin tolerance, RelB transcription activation requires binding to the (IkappaB alpha) proximal promoter along with NFKB1 (p50), and is associated with an apparent dimer exchange with RELA (p65).
PMID 19020113
[Homo sapiens] RELB functions as a dual transcription regulator during LPS tolerance and human severe systemic inflammation (SSI) by activating and repressing innate immunity genes.
PMID 21419662
[Homo sapiens] RELB is required for IL17A production in T cell in response to bacterial infection. RELB deficient T cells resulted in a diminished innate immune response to E. coli infection. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104856:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19606217-19629438
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000049912 ENSMUSP00000050166
ENSMUST00000094762 ENSMUSP00000092355
ENSMUST00000098754 ENSMUSP00000096350
ENSMUST00000148040
ENSMUST00000137615
ENSMUST00000131759
ENSMUST00000130543
ENSMUST00000153309
ENSMUST00000141586
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 18 [view]
Protein-DNA 20 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0019882 antigen processing and presentation
GO:0038061 NIK/NF-kappaB signaling
GO:0042088 T-helper 1 type immune response
GO:0043011 myeloid dendritic cell differentiation
GO:0045063 T-helper 1 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0071470 cellular response to osmotic stress
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104856
View Gene Order
ENSBTAG00000038428
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
nfkappabalternativepathway
Alternative NF-kappaB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1741
RefSeq NM_001290457 NM_009046 XM_006539674
OMIM
CCDS CCDS39799 CCDS71896
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca