Version 5.4
Homo sapiens Gene: APBB2
Summary
InnateDB Gene IDBG-15151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBB2
Gene Name amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms FE65L; FE65L1
Species Homo sapiens
Ensembl Gene ENSG00000163697
Encoded Proteins
IDBP-15153
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-473826
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-478791
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-484897
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-475529
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-481689
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-481304
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-482048
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-475875
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-483183
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-480112
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-478437
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-480714
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-476715
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-481401
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-482943
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-475210
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-483340
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-594198
amyloid beta (A4) precursor protein-binding, family B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer\'s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:40810027-41216714
Strand Reverse strand
Band p13
Transcripts
ENST00000295974 ENSP00000295974
ENST00000513140 ENSP00000426018
ENST00000513611 ENSP00000427307
ENST00000508593 ENSP00000427211
ENST00000502841 ENSP00000425802
ENST00000506352 ENSP00000421539
ENST00000504305 ENSP00000423765
ENST00000502687
ENST00000510925 ENSP00000422948
ENST00000512510 ENSP00000426429
ENST00000510670 ENSP00000427107
ENST00000514920 ENSP00000421751
ENST00000507831
ENST00000513516 ENSP00000421301
ENST00000513493 ENSP00000425121
ENST00000514094
ENST00000509475
ENST00000504484
ENST00000511120
ENST00000509446 ENSP00000424414
ENST00000508707 ENSP00000424579
ENST00000503264 ENSP00000425202
ENST00000508676 ENSP00000422723
ENST00000503503 ENSP00000421205
ENST00000506999
ENST00000503555
ENST00000511572
ENST00000502682
ENST00000505266
ENST00000543538 ENSP00000439357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0001764 neuron migration
GO:0006355 regulation of transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0007411 axon guidance
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029207
View Gene Order
ENSBTAG00000027569
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.479602 Hs.720643 Hs.734795
RefSeq NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054 NM_004307 NM_173075 XM_006714005 XM_006714006 XM_006714007 XM_006714008 XM_006714009 XM_006714010
HUGO
OMIM
CCDS CCDS43224 CCDS54760 CCDS54761 CCDS54762
HPRD 04088
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca