InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde6a

Summary

InnateDB Gene

IDBG-151653.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde6a

Gene Name

phosphodiesterase 6A, cGMP-specific, rod, alpha

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024575

Encoded Proteins

IDBP-151655

phosphodiesterase 6A, cGMP-specific, rod, alpha

IDBP-541372

phosphodiesterase 6A, cGMP-specific, rod, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132915:
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:61220482-61289924

Strand

Forward strand

Band

Transcripts

ENSMUST00000025468	ENSMUSP00000025468
ENSMUST00000135688	ENSMUSP00000115963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0046037	GMP metabolic process
GO:0051480	cytosolic calcium ion homeostasis
GO:0060041	retina development in camera-type eye