Version 5.4
Mus musculus Gene: Eef1d
Summary
InnateDB Gene IDBG-151679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eef1d
Gene Name eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Synonyms EF-1-delta
Species Mus musculus
Ensembl Gene ENSMUSG00000055762
Encoded Proteins
IDBP-151683
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-151685
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-151687
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-261249
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-261251
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-274125
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-541366
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-542086
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-541828
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-541093
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-539345
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-539704
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-540262
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-541338
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
IDBP-542508
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104529:
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75894796-75909556
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000023235 ENSMUSP00000023235
ENSMUST00000089680 ENSMUSP00000087109
ENSMUST00000089681 ENSMUSP00000087110
ENSMUST00000055220
ENSMUST00000109975 ENSMUSP00000105602
ENSMUST00000109972 ENSMUSP00000105599
ENSMUST00000116440 ENSMUSP00000112141
ENSMUST00000154584 ENSMUSP00000116360
ENSMUST00000151066 ENSMUSP00000118889
ENSMUST00000137426 ENSMUSP00000114753
ENSMUST00000134222
ENSMUST00000144614 ENSMUSP00000123005
ENSMUST00000141268 ENSMUSP00000115553
ENSMUST00000123712 ENSMUSP00000122155
ENSMUST00000129800
ENSMUST00000141475 ENSMUSP00000123388
ENSMUST00000127550 ENSMUSP00000120735
ENSMUST00000145764 ENSMUSP00000117782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003746 translation elongation factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006414 translational elongation
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005853 eukaryotic translation elongation factor 1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104529
View Gene Order
ENSBTAG00000014643
Not yet available
Pathways
NETPATH
REACTOME
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_232254
Eukaryotic Translation Elongation pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
REACT_226022
Gene Expression pathway
REACT_209048
Translation pathway
REACT_213782
Metabolism of proteins pathway
REACT_225811
Eukaryotic Translation Elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.258927
RefSeq NM_001285429 NM_001285430 NM_001285431 NM_001285432 NM_001285433 NM_001285434 NM_023240 NM_029663 XM_006521263 XM_006521264 XM_006521265 XM_006521271 XM_006521272 XM_006521274 XM_006521275
OMIM
CCDS CCDS27553 CCDS27554 CCDS70638 CCDS70639
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca