InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcg2

Summary

InnateDB Gene

IDBG-151752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg2

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 2

Synonyms

ABC15; ABCP; AI428558; BCRP; Bcrp1; MXR; MXR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029802

Encoded Proteins

IDBP-151754

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-252080

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-541676

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-541673

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-788294

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-532236

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-788298

ATP-binding cassette, sub-family G (WHITE), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:58584523-58692869

Strand

Forward strand

Band

Transcripts

ENSMUST00000031822	ENSMUSP00000031822
ENSMUST00000114294	ENSMUSP00000109933
ENSMUST00000147213	ENSMUSP00000120940
ENSMUST00000148008	ENSMUSP00000114454
ENSMUST00000124542
ENSMUST00000143752	ENSMUSP00000138608
ENSMUST00000145161	ENSMUSP00000122924
ENSMUST00000143447
ENSMUST00000145685	ENSMUSP00000138703
ENSMUST00000134426

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0015238	drug transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006855	drug transmembrane transport
GO:0010039	response to iron ion
GO:0015893	drug transport
GO:0042908	xenobiotic transport
GO:0046618	drug export
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid
GO:0060136	embryonic process involved in female pregnancy
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031966	mitochondrial membrane