InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppargc1b

Summary

InnateDB Gene

IDBG-151805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppargc1b

Gene Name

peroxisome proliferative activated receptor, gamma, coactivator 1 beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033871

Encoded Proteins

IDBP-151807

peroxisome proliferative activated receptor, gamma, coactivator 1 beta

IDBP-151809

peroxisome proliferative activated receptor, gamma, coactivator 1 beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21966468

Ppargc1b is activated in Staphylococcus aureus-mediated sepsis via the Tlr2-signalling pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21966468

[Homo sapiens] PPARGC1B is activated in Staphylococcus aureus-mediated sepsis via the TLR2-signalling pathway. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155846:
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:61298136-61400431

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075299	ENSMUSP00000074771
ENSMUST00000063307	ENSMUSP00000069431
ENSMUST00000142134

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030546	receptor activator activity
GO:0050682	AF-2 domain binding

Biological Process

GO:0001503	ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006390	transcription from mitochondrial promoter
GO:0007015	actin filament organization
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0034614	cellular response to reactive oxygen species
GO:0042327	positive regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060346	bone trabecula formation
GO:2000273	positive regulation of receptor activity