Version 5.4
Mus musculus Gene: Cacna1h
Summary
InnateDB Gene IDBG-151833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1h
Gene Name calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms alpha13.2; Cav3.2; MNCb-1209
Species Mus musculus
Ensembl Gene ENSMUSG00000024112
Encoded Proteins
IDBP-151837
calcium channel, voltage-dependent, T type, alpha 1H subunit
IDBP-542115
calcium channel, voltage-dependent, T type, alpha 1H subunit
IDBP-539231
calcium channel, voltage-dependent, T type, alpha 1H subunit
IDBP-534085
calcium channel, voltage-dependent, T type, alpha 1H subunit
IDBP-531904
calcium channel, voltage-dependent, T type, alpha 1H subunit
IDBP-534834
calcium channel, voltage-dependent, T type, alpha 1H subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-dependent Ca(2+) channels mediate the entry of Ca(2+) ions into excitable cells and are involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The protein encoded by this gene is an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25374285-25433783
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000078496 ENSMUSP00000077586
ENSMUST00000159610 ENSMUSP00000125541
ENSMUST00000159048 ENSMUSP00000123741
ENSMUST00000161035 ENSMUSP00000123906
ENSMUST00000161658 ENSMUSP00000124883
ENSMUST00000159331
ENSMUST00000162820
ENSMUST00000161454
ENSMUST00000159623 ENSMUSP00000125664
ENSMUST00000159052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005515 protein binding
GO:0008332 low voltage-gated calcium channel activity
GO:0097110 scaffold protein binding
Biological Process
GO:0006811 ion transport
GO:0032342 aldosterone biosynthetic process
GO:0032870 cellular response to hormone stimulus
GO:0034651 cortisol biosynthetic process
GO:0035865 cellular response to potassium ion
GO:0042391 regulation of membrane potential
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
GO:2000344 positive regulation of acrosome reaction
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196557
View Gene Order
ENSBTAG00000026461
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.268378 Mm.447208
RefSeq NM_001163691 NM_021415 XM_006524734
OMIM
CCDS CCDS37501
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca