Version 5.4
| Mus musculus Gene: Gp5 | |||||||
|---|---|---|---|---|---|---|---|
| Summary | |||||||
| InnateDB Gene | IDBG-151987.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Gp5 | ||||||
| Gene Name | glycoprotein 5 (platelet) | ||||||
| Synonyms | GPV | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000047953 | ||||||
| Encoded Proteins |
glycoprotein 5 (platelet)
|
||||||
| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178732:
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010] |
||||||
| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 16:30307686-30310779 | ||||||
| Strand | Reverse strand | ||||||
| Band | B2 | ||||||
| Transcripts |
|
||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||
| Gene Ontology | |||||||
Molecular Function |
|
||||||
| Biological Process |
|
||||||
| Cellular Component |
|
||||||
| Orthologs | |||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||
| Pathways | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
|
||||||
| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Platelet Adhesion to exposed collagen pathway
Intrinsic Pathway pathway
GP1b-IX-V activation signalling pathway
Platelet Aggregation (Plug Formation) pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Hemostasis pathway
|
||||||
| KEGG |
Hematopoietic cell lineage pathway
ECM-receptor interaction pathway
|
||||||
| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | Q9QZU3 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 14729 | ||||||
| UniGene | Mm.3519 | ||||||
| RefSeq | NM_008148 | ||||||
| OMIM | |||||||
| CCDS | CCDS28100 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:1096363 | ||||||
| MGI Symbol | Gp5 | ||||||
| EMBL | AC154608 AF163101 AK031272 | ||||||
| GenPept | AAF08787 BAC27331 | ||||||
| RNA Seq Atlas | 14729 | ||||||