InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtnr1a

Summary

InnateDB Gene

IDBG-152014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtnr1a

Gene Name

melatonin receptor 1A

Synonyms

MelR; MR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054764

Encoded Proteins

IDBP-152016

melatonin receptor 1A

IDBP-541726

melatonin receptor 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168412:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:45069137-45088356

Strand

Forward strand

Band

B1.1

Transcripts

ENSMUST00000067984	ENSMUSP00000069872
ENSMUST00000130141	ENSMUSP00000115764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008502	melatonin receptor activity
GO:0042562	hormone binding
GO:0097159	organic cyclic compound binding