Version 5.4
Homo sapiens Gene: RILP
Summary
InnateDB Gene IDBG-15202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RILP
Gene Name Rab interacting lysosomal protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167705
Encoded Proteins
IDBP-15206
Rab interacting lysosomal protein
IDBP-758660
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1646145-1650077
Strand Reverse strand
Band p13.3
Transcripts
ENST00000301336 ENSP00000301336
ENST00000574810 ENSP00000459101
ENST00000573398
ENST00000570858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0030670 phagocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038195
View Gene Order
ENSBTAG00000038889
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q96NA2
TrEMBL I3L1U0
UniProt Splice Variant
Entrez Gene 83547
UniGene Hs.534497
RefSeq NM_031430 XM_006721586 XM_006725256
HUGO HGNC:30266
OMIM 607848
CCDS CCDS11009
HPRD
IMGT
EMBL AC130343 AF370391 AJ278711 AJ404317 AK055755 AK314767 BC004961 BC031621
GenPept AAH04961 AAH31621 AAQ15227 BAB71003 BAG37305 CAC33443 CAC82174
RNA Seq Atlas 83547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca