Version 5.4
Mus musculus Gene: Cel
Summary
InnateDB Gene IDBG-152327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cel
Gene Name carboxyl ester lipase
Synonyms 1810036E18Rik; BAL
Species Mus musculus
Ensembl Gene ENSMUSG00000026818
Encoded Proteins
IDBP-152329
carboxyl ester lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170835:
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:28555795-28563403
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028161 ENSMUSP00000028161
ENSMUST00000124756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004771 sterol esterase activity
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008152 metabolic process
GO:0030157 pancreatic juice secretion
GO:0046514 ceramide catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170835
View Gene Order
ENSBTAG00000007486
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_204917
Digestion of dietary lipid pathway
KEGG
mmu00100
Steroid biosynthesis pathway
mmu00561
Glycerolipid metabolism pathway
mmu04972
Pancreatic secretion pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9518
Digestion of dietary lipid pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa00100
Steroid biosynthesis pathway
hsa00561
Glycerolipid metabolism pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.236017
RefSeq NM_009885 XM_006497643
OMIM
CCDS CCDS15841
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca