InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bdh1

Summary

InnateDB Gene

IDBG-152901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdh1

Gene Name

3-hydroxybutyrate dehydrogenase, type 1

Synonyms

2310032J20Rik; AI327223; Bdh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046598

Encoded Proteins

IDBP-152903

3-hydroxybutyrate dehydrogenase, type 1

IDBP-250104

3-hydroxybutyrate dehydrogenase, type 1

IDBP-250106

3-hydroxybutyrate dehydrogenase, type 1

IDBP-534774

3-hydroxybutyrate dehydrogenase, type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161267:
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:31422280-31458901

Strand

Forward strand

Band

Transcripts

ENSMUST00000089759	ENSMUSP00000087192
ENSMUST00000115227	ENSMUSP00000110882
ENSMUST00000115226	ENSMUSP00000110881
ENSMUST00000128286
ENSMUST00000149039	ENSMUSP00000119164
ENSMUST00000126825

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003858	3-hydroxybutyrate dehydrogenase activity
GO:0005543	phospholipid binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0001889	liver development
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0009725	response to hormone
GO:0032355	response to estradiol
GO:0032868	response to insulin
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0045471	response to ethanol
GO:0046686	response to cadmium ion
GO:0051412	response to corticosterone
GO:0055114	oxidation-reduction process
GO:0060416	response to growth hormone
GO:0060612	adipose tissue development