InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dlg1

Summary

InnateDB Gene

IDBG-152959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlg1

Gene Name

discs, large homolog 1 (Drosophila)

Synonyms

B130052P05Rik; Dlgh1; E-dlg/SAP97; mKIAA4187; SAP-97; SAP97

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022770

Encoded Proteins

IDBP-152961

discs, large homolog 1 (Drosophila)

IDBP-152963

discs, large homolog 1 (Drosophila)

IDBP-152965

discs, large homolog 1 (Drosophila)

IDBP-250116

discs, large homolog 1 (Drosophila)

IDBP-250118

discs, large homolog 1 (Drosophila)

IDBP-250122

discs, large homolog 1 (Drosophila)

IDBP-790424

discs, large homolog 1 (Drosophila)

IDBP-536383

discs, large homolog 1 (Drosophila)

IDBP-790425

discs, large homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075711:
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:31663443-31873356

Strand

Forward strand

Band

Transcripts

ENSMUST00000023454	ENSMUSP00000023454
ENSMUST00000100001	ENSMUSP00000097581
ENSMUST00000064477	ENSMUSP00000064280
ENSMUST00000115205	ENSMUSP00000110859
ENSMUST00000115201	ENSMUSP00000110855
ENSMUST00000115196	ENSMUSP00000110850
ENSMUST00000132176	ENSMUSP00000138782
ENSMUST00000155958
ENSMUST00000131136	ENSMUSP00000115954
ENSMUST00000137322
ENSMUST00000130920	ENSMUSP00000138804
ENSMUST00000147382
ENSMUST00000155847
ENSMUST00000138213
ENSMUST00000140258

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032947	protein complex scaffold
GO:0044325	ion channel binding
GO:0097016	L27 domain binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001771	immunological synapse formation
GO:0001935	endothelial cell proliferation
GO:0002088	lens development in camera-type eye
GO:0002369	T cell cytokine production
GO:0007015	actin filament organization
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030432	peristalsis
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0031579	membrane raft organization
GO:0031641	regulation of myelination
GO:0032147	activation of protein kinase activity
GO:0040018	positive regulation of multicellular organism growth
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0042391	regulation of membrane potential
GO:0042982	amyloid precursor protein metabolic process
GO:0043268	positive regulation of potassium ion transport
GO:0045930	negative regulation of mitotic cell cycle
GO:0048608	reproductive structure development
GO:0048639	positive regulation of developmental growth
GO:0048704	embryonic skeletal system morphogenesis
GO:0048729	tissue morphogenesis
GO:0048745	smooth muscle tissue development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051898	negative regulation of protein kinase B signaling
GO:0060022	hard palate development
GO:0070830	tight junction assembly
GO:0072659	protein localization to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0001772	immunological synapse
GO:0005605	basal lamina
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0005923	tight junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0031253	cell projection membrane
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier
GO:0035748	myelin sheath abaxonal region
GO:0043219	lateral loop
GO:0045121	membrane raft
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097025	MPP7-DLG1-LIN7 complex