InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Drd1a

Summary

InnateDB Gene

IDBG-153258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drd1a

Gene Name

dopamine receptor D1A

Synonyms

C030036C15Rik; Drd-1; Drd1; Gpcr15

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021478

Encoded Proteins

IDBP-153260

dopamine receptor D1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184845:
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:54051186-54055658

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021932

ENSMUSP00000021932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0035240	dopamine binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001661	conditioned taste aversion
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006606	protein import into nucleus
GO:0006936	muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014002	astrocyte development
GO:0015872	dopamine transport
GO:0019226	transmission of nerve impulse
GO:0019228	neuronal action potential
GO:0021542	dentate gyrus development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0030335	positive regulation of cell migration
GO:0030432	peristalsis
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0035106	operant conditioning
GO:0042053	regulation of dopamine metabolic process
GO:0042220	response to cocaine
GO:0042311	vasodilation
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0046323	glucose import
GO:0046959	habituation
GO:0046960	sensitization
GO:0048148	behavioral response to cocaine
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane