Version 5.4
Mus musculus Gene: Gls
Summary
InnateDB Gene IDBG-153335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gls
Gene Name glutaminase
Synonyms 6330442B14; AI314027; B230365M23Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026103
Encoded Proteins
IDBP-251606
glutaminase
IDBP-251608
glutaminase
IDBP-251610
glutaminase
IDBP-535646
glutaminase
IDBP-533106
glutaminase
IDBP-541067
glutaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115419:
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52163448-52233232
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000114513 ENSMUSP00000110158
ENSMUST00000114512 ENSMUSP00000110157
ENSMUST00000114510 ENSMUSP00000110155
ENSMUST00000114509
ENSMUST00000156887 ENSMUSP00000116901
ENSMUST00000136654
ENSMUST00000126221
ENSMUST00000138906
ENSMUST00000155587 ENSMUSP00000115358
ENSMUST00000129107 ENSMUSP00000121408
ENSMUST00000123324
ENSMUST00000139273
ENSMUST00000148917
ENSMUST00000147825
ENSMUST00000145514
ENSMUST00000151694
ENSMUST00000142976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004359 glutaminase activity
GO:0005515 protein binding
Biological Process
GO:0001967 suckling behavior
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006537 glutamate biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006543 glutamine catabolic process
GO:0007268 synaptic transmission
GO:0051289 protein homotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115419
View Gene Order
ENSBTAG00000007863
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_259290
Neuronal System pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
REACT_229514
Glutamate Neurotransmitter Release Cycle pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
mmu00471
D-Glutamine and D-glutamate metabolism pathway
mmu00330
Arginine and proline metabolism pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
mmu04964
Proximal tubule bicarbonate reclamation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.395289 Mm.398608 Mm.403924 Mm.487152
RefSeq NM_001081081 NM_001113383 XM_006495701 XM_006495702 XM_006495703
OMIM
CCDS CCDS35561 CCDS48256
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca