Version 5.4
Mus musculus Gene: Ncbp2
Summary
InnateDB Gene IDBG-153457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncbp2
Gene Name nuclear cap binding protein subunit 2
Synonyms 20kDa; 5930413E18Rik; AA536802; AI843301; C79367
Species Mus musculus
Ensembl Gene ENSMUSG00000022774
Encoded Proteins
IDBP-153459
nuclear cap binding protein subunit 2
IDBP-250195
nuclear cap binding protein subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114503:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5\' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3\'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31948513-31961781
Strand Forward strand
Band B2
Transcripts
ENSMUST00000023460 ENSMUSP00000023460
ENSMUST00000115178 ENSMUSP00000110832
ENSMUST00000140965
ENSMUST00000126215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006370 7-methylguanosine mRNA capping
GO:0006408 snRNA export from nucleus
GO:0006446 regulation of translational initiation
GO:0008380 RNA splicing
GO:0031047 gene silencing by RNA
GO:0045292 mRNA cis splicing, via spliceosome
GO:0046833 positive regulation of RNA export from nucleus
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005845 mRNA cap binding complex
GO:0005846 nuclear cap binding complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114503
View Gene Order
ENSBTAG00000008873
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_215668
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_224866
Metabolism of non-coding RNA pathway
REACT_198522
Nonsense-Mediated Decay (NMD) pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_198528
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_198524
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_232123
Processing of Intronless Pre-mRNAs pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_206812
snRNP Assembly pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_212343
Transport of the SLBP independent Mature mRNA pathway
REACT_235695
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_244199
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_250734
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_239127
Transport of the SLBP Dependant Mature mRNA pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_185
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1364
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1470
mRNA Capping pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_6256
HIV Life Cycle pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_6185
HIV Infection pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_207332
mRNA Capping pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_204974
Processing of Capped Intronless Pre-mRNA pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_205499
RNA Polymerase II Pre-transcription Events pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_207634
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_225310
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_226022
Gene Expression pathway
REACT_222208
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_220982
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_219798
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_219885
Transport of the SLBP independent Mature mRNA pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_206124
Metabolism of non-coding RNA pathway
REACT_213547
Transport of the SLBP Dependant Mature mRNA pathway
REACT_218933
RNA Polymerase II Transcription Elongation pathway
REACT_225642
Processing of Intronless Pre-mRNAs pathway
REACT_206737
Formation of RNA Pol II elongation complex pathway
REACT_216313
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_224480
snRNP Assembly pathway
REACT_217207
mRNA Splicing - Minor Pathway pathway
REACT_222777
Nonsense-Mediated Decay (NMD) pathway
REACT_205514
Formation of the Early Elongation Complex pathway
REACT_210287
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290027
RefSeq NM_026554
OMIM
CCDS CCDS28110
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca