InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hspa8

Summary

InnateDB Gene

IDBG-153613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa8

Gene Name

heat shock protein 8

Synonyms

2410008N15Rik; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015656

Encoded Proteins

IDBP-153615

heat shock protein 8

IDBP-401323

heat shock protein 8

IDBP-401319

heat shock protein 8

IDBP-538144

heat shock protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109971:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:40800984-40805200

Strand

Forward strand

Band

A5.1

Transcripts

ENSMUST00000015800	ENSMUSP00000015800
ENSMUST00000117870	ENSMUSP00000114081
ENSMUST00000117557	ENSMUSP00000113722
ENSMUST00000149936
ENSMUST00000153847
ENSMUST00000140984
ENSMUST00000138895
ENSMUST00000133964	ENSMUSP00000117285
ENSMUST00000127699

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 255 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	255 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0023026	MHC class II protein complex binding
GO:0031072	heat shock protein binding
GO:0042623	ATPase activity, coupled
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0006950	response to stress
GO:0008380	RNA splicing
GO:0042026	protein refolding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051726	regulation of cell cycle
GO:0072318	clathrin coat disassembly
GO:1902904	negative regulation of fibril organization

Cellular Component

GO:0000974	Prp19 complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000109971

View Gene Order

ENSBTAG00000013162

Not yet available

Pathways

NETPATH

REACTOME

REACT_249110

mRNA Splicing pathway

REACT_209837

Membrane Trafficking pathway

REACT_245631

GABA synthesis, release, reuptake and degradation pathway

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_188957

Cellular responses to stress pathway

REACT_198693

AUF1 (hnRNP D0) destabilizes mRNA pathway

REACT_231722

Lysosome Vesicle Biogenesis pathway

REACT_232671

Golgi Associated Vesicle Biogenesis pathway

REACT_213550

HSF1-dependent transactivation pathway

REACT_224790

Cellular response to heat stress pathway

REACT_250087

Neurotransmitter Release Cycle pathway

REACT_223784

Attenuation phase pathway

REACT_243409

trans-Golgi Network Vesicle Budding pathway

REACT_234979

Clathrin derived vesicle budding pathway

REACT_233572

Gene Expression pathway

REACT_259290

Neuronal System pathway

REACT_260226

mRNA Splicing - Major Pathway pathway

REACT_222185

Regulation of HSF1-mediated heat shock response pathway

REACT_233318

Transmission across Chemical Synapses pathway

REACT_233950

Processing of Capped Intron-Containing Pre-mRNA pathway

KEGG

mmu04612

Antigen processing and presentation pathway

mmu04010

MAPK signaling pathway pathway

mmu04144

Endocytosis pathway

mmu03040

Spliceosome pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

mmu05145

Toxoplasmosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

NetPath_21

RANKL pathway

NetPath_23

TSH pathway

REACTOME

REACT_25325

AUF1 (hnRNP D0) destabilizes mRNA pathway

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_23947

GABA synthesis, release, reuptake and degradation pathway

REACT_19287

Lysosome Vesicle Biogenesis pathway

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_22292

CHL1 interactions pathway

REACT_22205

L1CAM interactions pathway

REACT_120956

Cellular responses to stress pathway

REACT_111045

Developmental Biology pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_200780

Regulation of HSF1-mediated heat shock response pathway

REACT_13685

Neuronal System pathway

REACT_200624

Attenuation phase pathway

REACT_18266

Axon guidance pathway

REACT_200775

HSF1-dependent transactivation pathway

REACT_200819

Cellular response to heat stress pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

REACT_11123

Membrane Trafficking pathway

REACT_218726

Regulation of HSF1-mediated heat shock response pathway

REACT_205948

mRNA Splicing - Major Pathway pathway

REACT_205580

HSF1-dependent transactivation pathway

REACT_206725

mRNA Splicing pathway

REACT_226413

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_215526

L1CAM interactions pathway

REACT_206069

Cellular responses to stress pathway

REACT_226022

Gene Expression pathway

REACT_227515

AUF1 (hnRNP D0) destabilizes mRNA pathway

REACT_226302

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_203140

Axon guidance pathway

REACT_225257

Cellular response to heat stress pathway

REACT_214880

CHL1 interactions pathway

REACT_213591

Attenuation phase pathway

REACT_220844

Developmental Biology pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04612

Antigen processing and presentation pathway

hsa04144

Endocytosis pathway

hsa03040

Spliceosome pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.290774 Mm.336743 Mm.426378 Mm.472965

RefSeq

NM_031165

OMIM

CCDS

CCDS23083

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas