Version 5.4
Mus musculus Gene: Pigx
Summary
InnateDB Gene IDBG-153664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigx
Gene Name phosphatidylinositol glycan anchor biosynthesis, class X
Synonyms 2010319C14Rik; PIG-X
Species Mus musculus
Ensembl Gene ENSMUSG00000023791
Encoded Proteins
IDBP-153668
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-541900
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-532268
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-539472
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-532890
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-537868
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-541183
phosphatidylinositol glycan anchor biosynthesis, class X
IDBP-789868
phosphatidylinositol glycan anchor biosynthesis, class X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:32084418-32099738
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000096109 ENSMUSP00000093819
ENSMUST00000151250
ENSMUST00000143011
ENSMUST00000155966 ENSMUSP00000114854
ENSMUST00000147688 ENSMUSP00000121801
ENSMUST00000147003 ENSMUSP00000120272
ENSMUST00000133584 ENSMUSP00000119754
ENSMUST00000136643 ENSMUSP00000118256
ENSMUST00000135677
ENSMUST00000144216 ENSMUSP00000122511
ENSMUST00000189013 ENSMUSP00000141122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006506 GPI anchor biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163964
View Gene Order
ENSBTAG00000048195
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001111025 NM_024464
OMIM
CCDS CCDS28113 CCDS49824
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca