Mus musculus Gene: Il12rb2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-153874.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Il12rb2 | ||||||||||||||||||||||
Gene Name | interleukin 12 receptor, beta 2 | ||||||||||||||||||||||
Synonyms | A930027I18Rik; Ifnm; IL-12RB2 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000018341 | ||||||||||||||||||||||
Encoded Proteins |
interleukin 12 receptor, beta 2
interleukin 12 receptor, beta 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081985:
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn\'s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:67291318-67376188 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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INOH |
JAK STAT pathway and regulation pathway
IL-12 signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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INOH |
JAK STAT pathway and regulation pathway
IL-12 signaling pathway
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PID NCI |
IL27-mediated signaling events
IL12-mediated signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | P97378 | ||||||||||||||||||||||
TrEMBL | D3Z6H5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 16162 | ||||||||||||||||||||||
UniGene | Mm.188337 | ||||||||||||||||||||||
RefSeq | NM_008354 XM_006505617 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS20220 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1270861 | ||||||||||||||||||||||
MGI Symbol | Il12rb2 | ||||||||||||||||||||||
EMBL | AC130822 BC137745 U64199 | ||||||||||||||||||||||
GenPept | AAB36676 AAI37746 | ||||||||||||||||||||||
RNA Seq Atlas | 16162 | ||||||||||||||||||||||