Version 5.4
Mus musculus Gene: Nedd4l
Summary
InnateDB Gene IDBG-154290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nedd4l
Gene Name neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms 1300012C07Rik; Nedd4-2; Nedd4b
Species Mus musculus
Ensembl Gene ENSMUSG00000024589
Encoded Proteins
IDBP-154294
neural precursor cell expressed, developmentally down-regulated gene 4-like
IDBP-623398
neural precursor cell expressed, developmentally down-regulated gene 4-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049759:
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:64887756-65217826
Strand Forward strand
Band E1
Transcripts
ENSMUST00000080418 ENSMUSP00000079280
ENSMUST00000163516 ENSMUSP00000132838
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 140 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 140 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0016874 ligase activity
GO:0017080 sodium channel regulator activity
GO:0019870 potassium channel inhibitor activity
GO:0019871 sodium channel inhibitor activity
GO:0044325 ion channel binding
Biological Process
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003254 regulation of membrane depolarization
GO:0006513 protein monoubiquitination
GO:0009651 response to salt stress
GO:0010038 response to metal ion
GO:0010765 positive regulation of sodium ion transport
GO:0010766 negative regulation of sodium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045732 positive regulation of protein catabolic process
GO:0060306 regulation of membrane repolarization
GO:0070936 protein K48-linked ubiquitination
GO:0086005 ventricular cardiac muscle cell action potential
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:2000009 negative regulation of protein localization to cell surface
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2000810 regulation of tight junction assembly
GO:2001259 positive regulation of cation channel activity
GO:2001288 positive regulation of caveolin-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000049759
View Gene Order
ENSBTAG00000005412
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04144
Endocytosis pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_160189
Stimuli-sensing channels pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_25300
Ion channel transport pathway
REACT_6256
HIV Life Cycle pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_6185
HIV Infection pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04144
Endocytosis pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p73pathway
p73 transcription factor network
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL E9PXB7 G3X9H8
UniProt Splice Variant
Entrez Gene 83814
UniGene Mm.401832 Mm.423409 Mm.98668
RefSeq NM_001114386 NM_031881 XM_006526368 XM_006526370 XM_006526372 XM_006526374 XM_006526375 XM_006526376 XM_006526377 XM_006526378 XM_006526379 XM_006526380 XM_006526382
OMIM
CCDS CCDS29305 CCDS50309
HPRD
IMGT
MGI ID MGI:1933754
MGI Symbol Nedd4l
EMBL AC102288 AC102333 AC131709 AC161175 CH466528
GenPept EDL09694
RNA Seq Atlas 83814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca