Version 5.4
Mus musculus Gene: Xpo1
Summary
InnateDB Gene IDBG-154345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xpo1
Gene Name exportin 1, CRM1 homolog (yeast)
Synonyms AA420417; Crm1; Exp1
Species Mus musculus
Ensembl Gene ENSMUSG00000020290
Encoded Proteins
IDBP-154347
exportin 1, CRM1 homolog (yeast)
IDBP-154349
exportin 1, CRM1 homolog (yeast)
IDBP-154351
exportin 1, CRM1 homolog (yeast)
IDBP-262148
exportin 1, CRM1 homolog (yeast)
IDBP-532816
exportin 1, CRM1 homolog (yeast)
IDBP-542446
exportin 1, CRM1 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082898:
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:23256041-23298249
Strand Forward strand
Band A3.2
Transcripts
ENSMUST00000020538 ENSMUSP00000020538
ENSMUST00000102870 ENSMUSP00000099934
ENSMUST00000102869 ENSMUSP00000099933
ENSMUST00000109551 ENSMUSP00000105178
ENSMUST00000149371
ENSMUST00000136235 ENSMUSP00000123634
ENSMUST00000150750 ENSMUSP00000117846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 137 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005487 nucleocytoplasmic transporter activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
GO:0019904 protein domain specific binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0010824 regulation of centrosome duplication
GO:0034504 protein localization to nucleus
GO:0042176 regulation of protein catabolic process
GO:0042493 response to drug
GO:0046825 regulation of protein export from nucleus
GO:0051028 mRNA transport
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005642 annulate lamellae
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000082898
View Gene Order
ENSBTAG00000013254
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_215733
Downregulation of TGF-beta receptor signaling pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_198691
HuR stabilizes mRNA pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_202512
Mitotic Anaphase pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_25218
HuR stabilizes mRNA pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6179
NEP/NS2 Interacts with the Cellular Export Machinery pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_6167
Influenza Infection pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_2203
G2/M Transition pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_6185
HIV Infection pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_6145
Influenza Life Cycle pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_6296
Export of Viral Ribonucleoproteins from Nucleus pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
foxopathway
FoxO family signaling
hdac_classi_pathway
Signaling events mediated by HDAC Class I
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ilk_pathway
Integrin-linked kinase signaling
hdac_classii_pathway
Signaling events mediated by HDAC Class II
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt Q6P5F9
TrEMBL A2AKT6 Q8BYY5 Q921J0
UniProt Splice Variant
Entrez Gene 103573
UniGene
RefSeq NM_001035226 XM_006514431 XM_006514432 NM_134014 XM_006514430
OMIM
CCDS CCDS24475
HPRD
IMGT
MGI ID MGI:2144013
MGI Symbol Xpo1
EMBL AK037196 AL772359 BC012276 BC025628 BC062912
GenPept AAH12276 AAH25628 AAH62912 BAC29747
RNA Seq Atlas 103573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca