InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spna2

Summary

InnateDB Gene

IDBG-154896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spna2

Gene Name

spectrin alpha 2

Synonyms

2610027H02Rik; Spna-2; Spna2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057738

Encoded Proteins

IDBP-154898

spectrin alpha 2

IDBP-154900

spectrin alpha 2

IDBP-154902

spectrin alpha 2

IDBP-253233

spectrin alpha 2

IDBP-253235

spectrin alpha 2

IDBP-253237

spectrin alpha 2

IDBP-532774

spectrin alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197694:
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:29965560-30031451

Strand

Forward strand

Band

Transcripts

ENSMUST00000100225	ENSMUSP00000097797
ENSMUST00000095083	ENSMUSP00000092697
ENSMUST00000046257	ENSMUSP00000047792
ENSMUST00000113741	ENSMUSP00000109370
ENSMUST00000113719	ENSMUSP00000109348
ENSMUST00000113717	ENSMUSP00000109346
ENSMUST00000143918
ENSMUST00000131827
ENSMUST00000149038
ENSMUST00000149846
ENSMUST00000129241	ENSMUSP00000121116
ENSMUST00000124494
ENSMUST00000152453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	102 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030507	spectrin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0051693

actin filament capping

Cellular Component

GO:0005916	fascia adherens
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate
GO:0033270	paranode region of axon
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome