InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs11

Summary

InnateDB Gene

IDBG-154931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs11

Gene Name

regulator of G-protein signaling 11

Synonyms

C78048

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024186

Encoded Proteins

IDBP-154933

regulator of G-protein signaling 11

IDBP-401403

regulator of G-protein signaling 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076344:
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:26202951-26211324

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000025020	ENSMUSP00000025020
ENSMUST00000122058	ENSMUSP00000113885
ENSMUST00000152676
ENSMUST00000126464
ENSMUST00000152299
ENSMUST00000147220
ENSMUST00000146683
ENSMUST00000127594
ENSMUST00000123670
ENSMUST00000155072
ENSMUST00000139639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0044292	dendrite terminus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000076344

View Gene Order

ENSBTAG00000016574

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.109840

RefSeq

NM_001081069

OMIM

CCDS

CCDS37511

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas