InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AP3D1

Summary

InnateDB Gene

IDBG-15496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP3D1

Gene Name

adaptor-related protein complex 3, delta 1 subunit

Synonyms

ADTD; hBLVR

Species

Homo sapiens

Ensembl Gene

ENSG00000065000

Encoded Proteins

IDBP-15498

adaptor-related protein complex 3, delta 1 subunit

IDBP-15506

adaptor-related protein complex 3, delta 1 subunit

IDBP-764315

IDBP-761291

IDBP-809152

adaptor-related protein complex 3, delta 1 subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:2100988-2164465

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000345016	ENSP00000344055
ENST00000355272	ENSP00000347416
ENST00000591631
ENST00000591650
ENST00000586177
ENST00000585652
ENST00000592488
ENST00000591284
ENST00000589369	ENSP00000466267
ENST00000586370	ENSP00000468449
ENST00000590683	ENSP00000481961
ENST00000589223

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005488	binding
GO:0008565	protein transporter activity

Biological Process

GO:0006726	eye pigment biosynthetic process
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0019882	antigen processing and presentation
GO:0032438	melanosome organization
GO:0033365	protein localization to organelle
GO:0035646	endosome to melanosome transport
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490	anterograde synaptic vesicle transport
GO:0048499	synaptic vesicle membrane organization
GO:0051138	positive regulation of NK T cell differentiation
GO:0061088	regulation of sequestering of zinc ion
GO:0072657	protein localization to membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030424	axon
GO:0043195	terminal bouton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020198

View Gene Order

ENSBTAG00000009034

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04142

Lysosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

8943

UniGene

Hs.512815 Hs.599017 Hs.619533

RefSeq

NM_001261826 NM_003938

HUGO

HGNC:568

OMIM

607246

CCDS

CCDS42459 CCDS58638

HPRD

06260

IMGT

EMBL

GenPept

RNA Seq Atlas

8943