InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf4

Summary

InnateDB Gene

IDBG-155018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf4

Gene Name

ring finger protein 4

Synonyms

AU018689; Gtrgeo8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029110

Encoded Proteins

IDBP-155020

ring finger protein 4

IDBP-789891

ring finger protein 4

IDBP-789892

ring finger protein 4

IDBP-789893

ring finger protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063978:
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:34336289-34355629

Strand

Forward strand

Band

Transcripts

ENSMUST00000030992	ENSMUSP00000030992
ENSMUST00000182709	ENSMUSP00000138555
ENSMUST00000182970
ENSMUST00000181999
ENSMUST00000181991
ENSMUST00000182582
ENSMUST00000182772
ENSMUST00000183071
ENSMUST00000182583	ENSMUSP00000138594
ENSMUST00000182047	ENSMUSP00000138411
ENSMUST00000182810
ENSMUST00000183265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031491	nucleosome binding
GO:0032184	SUMO polymer binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046685	response to arsenic-containing substance
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination
GO:0090169	regulation of spindle assembly
GO:0090234	regulation of kinetochore assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0016605	PML body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000063978

View Gene Order

ENSBTAG00000027453

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_011278 XM_006503803 XM_006503804 XM_006503805

OMIM

CCDS

CCDS57336

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas