Version 5.4
Mus musculus Gene: Sgpl1
Summary
InnateDB Gene IDBG-155094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgpl1
Gene Name sphingosine phosphate lyase 1
Synonyms AI428538; D10Xrf456; S1PL; Spl
Species Mus musculus
Ensembl Gene ENSMUSG00000020097
Encoded Proteins
IDBP-155096
sphingosine phosphate lyase 1
IDBP-401250
sphingosine phosphate lyase 1
IDBP-539740
sphingosine phosphate lyase 1
IDBP-536794
sphingosine phosphate lyase 1
IDBP-533334
sphingosine phosphate lyase 1
IDBP-536281
sphingosine phosphate lyase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166224:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:61098642-61147703
Strand Reverse strand
Band B4
Transcripts
ENSMUST00000092498 ENSMUSP00000090155
ENSMUST00000122259 ENSMUSP00000112975
ENSMUST00000150258 ENSMUSP00000117848
ENSMUST00000143225
ENSMUST00000152316
ENSMUST00000155919 ENSMUSP00000115561
ENSMUST00000137833 ENSMUSP00000119550
ENSMUST00000142192
ENSMUST00000126307 ENSMUSP00000115907
ENSMUST00000124896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008117 sphinganine-1-phosphate aldolase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001553 luteinization
GO:0001570 vasculogenesis
GO:0001822 kidney development
GO:0006631 fatty acid metabolic process
GO:0006672 ceramide metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008585 female gonad development
GO:0009058 biosynthetic process
GO:0009791 post-embryonic development
GO:0010761 fibroblast migration
GO:0019752 carboxylic acid metabolic process
GO:0030097 hemopoiesis
GO:0033327 Leydig cell differentiation
GO:0040014 regulation of multicellular organism growth
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048705 skeletal system morphogenesis
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166224
View Gene Order
ENSBTAG00000009984
Not yet available
Pathways
NETPATH
REACTOME
REACT_198151
Sphingolipid de novo biosynthesis pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
s1p_meta_pathway
Sphingosine 1-phosphate (S1P) pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.412319 Mm.414458
RefSeq NM_009163 XM_006513402 XM_006513403 XM_006513404
OMIM
CCDS CCDS35914
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca