Version 5.4
Mus musculus Gene: Dusp1
Summary
InnateDB Gene IDBG-155234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp1
Gene Name dual specificity phosphatase 1
Synonyms 3CH134; erp; mkp-1; MKP1; Ptpn16; U19515
Species Mus musculus
Ensembl Gene ENSMUSG00000024190
Encoded Proteins
IDBP-155236
dual specificity phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21959016
Dusp1 is a negative regulator of MAPK-dependent induction of Il6 and Il8 in response to the coronavirus infectious bronchitis virus (IBV). (Demonstrated in human)
PMID 22464096
Dusp1 antagonizes p38 MAPK activity to induce Il12b expression, and may play a role in the development of Th1 type immune response and anti-microbial defence.
PMID 26019272
Dusp1 modulates the phosphorylation status of mRNA-destabilizing protein Zfp36 to regulate macrophage immune response to lipopolysaccharide.
InnateDB Annotation from Orthologs
Summary
PMID 18504304
[Homo sapiens] DUSP1 inhibits MAPK pathways and decreases TLR signalling.
PMID 19436832
[Homo sapiens] DUSP1 is an essential feedback regulator of the innate immune response, it plays a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection and plays a pivotal role in the deactivation of MAPK1 and MAPK8.
PMID 21959016
[Homo sapiens] DUSP1 is a negative regulator of MAPK-dependent induction of IL6 and IL8 in response to the coronavirus infectious bronchitis virus (IBV).
PMID 22464096
[Homo sapiens] DUSP1 antagonizes p38 MAPK activity to induce IL12B expression, and may play a role in the development of Th1 type immune response and anti-microbial defence. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120129:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:26505590-26508519
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000025025 ENSMUSP00000025025
ENSMUST00000126178
ENSMUST00000146077
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0006470 protein dephosphorylation
GO:0009416 response to light stimulus
GO:0010033 response to organic substance
GO:0016311 dephosphorylation
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032870 cellular response to hormone stimulus
GO:0033574 response to testosterone
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0051384 response to glucocorticoid
GO:0051447 negative regulation of meiotic cell cycle
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071850 mitotic cell cycle arrest
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120129
View Gene Order
ENSBTAG00000013863
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
ap1_pathway
AP-1 transcription factor network
p38alphabetapathway
Regulation of p38-alpha and p38-beta
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P28563
TrEMBL Q3U8K3
UniProt Splice Variant
Entrez Gene 19252
UniGene Mm.239041 Mm.470881
RefSeq NM_013642
OMIM
CCDS CCDS28552
HPRD
IMGT
MGI ID MGI:105120
MGI Symbol Dusp1
EMBL AK149915 AK152183 AK152324 AK159251 AK159363 AK159567 AK159658 AK159726 AK167602 AK168627 BC006967 CH466606 S64851 X61940
GenPept AAB27882 AAH06967 BAE29163 BAE31014 BAE31126 BAE34932 BAE35021 BAE35190 BAE35267 BAE35320 BAE39659 BAE40487 CAA43944 EDL22508
RNA Seq Atlas 19252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca