InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxw7

Summary

InnateDB Gene

IDBG-155472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw7

Gene Name

F-box and WD-40 domain protein 7

Synonyms

1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; SEL-10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028086

Encoded Proteins

IDBP-155474

F-box and WD-40 domain protein 7

IDBP-266146

F-box and WD-40 domain protein 7

IDBP-266148

F-box and WD-40 domain protein 7

IDBP-266152

F-box and WD-40 domain protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109670:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:84815268-84979198

Strand

Forward strand

Band

Transcripts

ENSMUST00000029727	ENSMUSP00000029727
ENSMUST00000107679	ENSMUSP00000103306
ENSMUST00000107678	ENSMUSP00000103305
ENSMUST00000107675	ENSMUSP00000103302
ENSMUST00000151410

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007062	sister chromatid cohesion
GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0030324	lung development
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032876	negative regulation of DNA endoreduplication
GO:0034644	cellular response to UV
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0050821	protein stabilization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm