InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Emd

Summary

InnateDB Gene

IDBG-155498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emd

Gene Name

emerin

Synonyms

AW550900; Sta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001964

Encoded Proteins

IDBP-148848

emerin

IDBP-155500

emerin

IDBP-155502

emerin

IDBP-400974

emerin

IDBP-534355

emerin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is the founding member of the LEM (Lap2beta, Emerin, and Man1) domain gene family. It encodes an integral membrane protein of the inner nuclear membrane. This gene may be involved in transcriptional regulation and genomic organization. In humans, mutations in this gene cause a class of diseases called laminopathies, which includes Emery-Dreifuss muscular dystrophy (EDMD). [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:74254687-74261548

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000096424	ENSMUSP00000094158
ENSMUST00000088313	ENSMUSP00000094133
ENSMUST00000002029	ENSMUSP00000002029
ENSMUST00000119197	ENSMUSP00000112639
ENSMUST00000129516
ENSMUST00000152288	ENSMUSP00000115890

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0035414	negative regulation of catenin import into nucleus
GO:0035914	skeletal muscle cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0048147	negative regulation of fibroblast proliferation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005652	nuclear lamina
GO:0005783	endoplasmic reticulum
GO:0005874	microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane