Version 5.4
Mus musculus Gene: Smarca2
Summary
InnateDB Gene IDBG-155600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smarca2
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms 2610209L14Rik; brahma; brm; SNF2alpha; Snf2l2
Species Mus musculus
Ensembl Gene ENSMUSG00000024921
Encoded Proteins
IDBP-155602
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-155604
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-255582
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-704419
IDBP-705443
IDBP-704486
IDBP-704996
IDBP-704983
IDBP-704435
IDBP-704554
IDBP-705261
IDBP-705149
IDBP-704747
IDBP-704199
IDBP-705186
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19144648
[Homo sapiens] A member of the SWI/SNF family of proteins and is essential for the multiple changes in gene expression that occur during differentiation
PMID 19342595
[Homo sapiens] Required for maintaining expression of several smooth muscle-specific genes
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080503:
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:26605115-26778321
Strand Forward strand
Band C1
Transcripts
ENSMUST00000025862 ENSMUSP00000025862
ENSMUST00000099537 ENSMUSP00000097135
ENSMUST00000112637 ENSMUSP00000108256
ENSMUST00000176030 ENSMUSP00000135784
ENSMUST00000176584 ENSMUSP00000135344
ENSMUST00000177116 ENSMUSP00000135116
ENSMUST00000175935
ENSMUST00000176769 ENSMUSP00000135017
ENSMUST00000175842 ENSMUSP00000135800
ENSMUST00000176698 ENSMUSP00000134914
ENSMUST00000175953 ENSMUSP00000135042
ENSMUST00000177484 ENSMUSP00000135869
ENSMUST00000176731 ENSMUSP00000135460
ENSMUST00000176019
ENSMUST00000175791 ENSMUSP00000135412
ENSMUST00000176700
ENSMUST00000177252 ENSMUSP00000134995
ENSMUST00000176475 ENSMUSP00000135248
ENSMUST00000176494
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 88 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042393 histone binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0030308 negative regulation of cell growth
GO:0035887 aortic smooth muscle cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0043231 intracellular membrane-bounded organelle
GO:0045111 intermediate filament cytoskeleton
GO:0071564 npBAF complex
GO:0071565 nBAF complex
GO:0071778 WINAC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000080503
View Gene Order
ENSBTAG00000007494
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.313303 Mm.408448 Mm.490734
RefSeq NM_011416 NM_026003 XM_006527281 XM_006527282 XM_006527283 XM_006527284 XM_006527285 XM_006527286 XM_006527287 XM_006527290 XM_006527291
OMIM
CCDS CCDS29720 CCDS37945
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca