InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnc

Summary

InnateDB Gene

IDBG-155840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnc

Gene Name

tenascin C

Synonyms

AI528729; C130033P17Rik; cytotactin; Hxb; Ten; tenascin-C; TN; TN-C

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028364

Encoded Proteins

IDBP-155842

tenascin C

IDBP-266796

tenascin C

IDBP-266802

tenascin C

IDBP-266804

tenascin C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000041982:
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:63959785-64047015

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030056	ENSMUSP00000030056
ENSMUST00000107377	ENSMUSP00000103000
ENSMUST00000107372	ENSMUSP00000102995
ENSMUST00000107371	ENSMUSP00000102994

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045545	syndecan binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007528	neuromuscular junction development
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0010628	positive regulation of gene expression
GO:0014012	peripheral nervous system axon regeneration
GO:0031175	neuron projection development
GO:0042060	wound healing
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045471	response to ethanol
GO:0060447	bud outgrowth involved in lung branching
GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development
GO:0060740	prostate gland epithelium morphogenesis
GO:0071300	cellular response to retinoic acid
GO:0071305	cellular response to vitamin D
GO:0071774	response to fibroblast growth factor
GO:0071799	cellular response to prostaglandin D stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix