Version 5.4
Mus musculus Gene: Grk4
Summary
InnateDB Gene IDBG-155868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grk4
Gene Name G protein-coupled receptor kinase 4
Synonyms A830025H08Rik; Gprk2l; Gprk4; GRK
Species Mus musculus
Ensembl Gene ENSMUSG00000052783
Encoded Proteins
IDBP-155870
G protein-coupled receptor kinase 4
IDBP-155872
G protein-coupled receptor kinase 4
IDBP-532735
G protein-coupled receptor kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125388:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq, Jul 2008]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:34660379-34755305
Strand Forward strand
Band B2
Transcripts
ENSMUST00000074651 ENSMUSP00000074223
ENSMUST00000001112 ENSMUSP00000001112
ENSMUST00000148588 ENSMUSP00000122826
ENSMUST00000153323
ENSMUST00000134217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031 G-protein coupled receptor internalization
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0031623 receptor internalization
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125388
View Gene Order
ENSBTAG00000001505
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_25
FSH pathway
REACTOME
KEGG
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt O70291
TrEMBL
UniProt Splice Variant
Entrez Gene 14772
UniGene Mm.117076
RefSeq NM_019497 XM_006503740 NM_001080743
OMIM
CCDS CCDS19219 CCDS39070
HPRD
IMGT
MGI ID MGI:95801
MGI Symbol Grk4
EMBL AF040745 AK132685 BC150691 CH466524
GenPept AAC09266 AAI50692 BAE21301 EDL37466
RNA Seq Atlas 14772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca