Mus musculus Gene: Kalrn | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-155984.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Kalrn | ||||||||||||||||||||||
Gene Name | kalirin, RhoGEF kinase | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000061751 | ||||||||||||||||||||||
Encoded Proteins |
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
kalirin, RhoGEF kinase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160145:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Huntington\'s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 16:33974258-34573532 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-Ephrin signaling pathway
G alpha (12/13) signalling events pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Developmental Biology pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
NRAGE signals death through JNK pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Developmental Biology pathway
Signalling by NGF pathway
EPHB-mediated forward signaling pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-Ephrin signaling pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Regulation of RAC1 activity
EPHB forward signaling
Arf6 downstream pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D3Z559 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 545156 | ||||||||||||||||||||||
UniGene | Mm.400459 Mm.462523 Mm.476308 Mm.479108 Mm.82274 | ||||||||||||||||||||||
RefSeq | NM_001164268 NM_177357 XM_006522364 XM_006522367 XM_006522368 XM_006522372 XM_006522382 XM_006522383 XM_006522385 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS49836 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:2685385 | ||||||||||||||||||||||
MGI Symbol | Kalrn | ||||||||||||||||||||||
EMBL | AC154524 AC154588 AC155257 AC165079 CT010573 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 545156 | ||||||||||||||||||||||