Version 5.4
Homo sapiens Gene: LACTB
Summary
InnateDB Gene IDBG-15609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LACTB
Gene Name lactamase, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103642
Encoded Proteins
IDBP-15613
lactamase, beta
IDBP-374702
lactamase, beta
IDBP-597166
lactamase, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamases but most of the residues that are responsible for the beta-lactamase activity are not conserved between the two proteins. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:63121800-63142061
Strand Forward strand
Band q22.2
Transcripts
ENST00000261893 ENSP00000261893
ENST00000413507 ENSP00000392956
ENST00000557972 ENSP00000454085
ENST00000559782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032370
View Gene Order
ENSBTAG00000017373
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410388
RefSeq NM_001288585 NM_032857 NM_171846
HUGO
OMIM
CCDS CCDS10182 CCDS45275
HPRD 07466
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca