Version 5.4
Mus musculus Gene: Vsx2
Summary
InnateDB Gene IDBG-156854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vsx2
Gene Name visual system homeobox 2
Synonyms Chx10; Hox-10; Hox10; or
Species Mus musculus
Ensembl Gene ENSMUSG00000021239
Encoded Proteins
IDBP-156856
visual system homeobox 2
IDBP-621176
visual system homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:84569762-84595457
Strand Forward strand
Band D1
Transcripts
ENSMUST00000021665 ENSMUSP00000021665
ENSMUST00000169934 ENSMUSP00000131009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0043010 camera-type eye development
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060040 retinal bipolar neuron differentiation
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119614
View Gene Order
ENSBTAG00000014632
Not yet available
Cross-References
SwissProt
TrEMBL Q3TSC7 Q6PDC1
UniProt Splice Variant
Entrez Gene 12677
UniGene Mm.4405
RefSeq XM_006515453 NM_007701
OMIM
CCDS CCDS36493
HPRD
IMGT
MGI ID MGI:88401
MGI Symbol Vsx2
EMBL AC110564 AK162139 BC058806 CH466590
GenPept AAH58806 BAE36748 EDL02809
RNA Seq Atlas 12677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca