InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: H2afy

Summary

InnateDB Gene

IDBG-156982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2afy

Gene Name

H2A histone family, member Y

Synonyms

H2AF12M; macroH2A1; mH2a1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015937

Encoded Proteins

IDBP-156984

H2A histone family, member Y

IDBP-156986

H2A histone family, member Y

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113648:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:56073619-56136361

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016081	ENSMUSP00000016081
ENSMUST00000045788	ENSMUSP00000038221
ENSMUST00000137835
ENSMUST00000141589
ENSMUST00000139511
ENSMUST00000141031
ENSMUST00000154778
ENSMUST00000154564

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000182	rDNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0010385	double-stranded methylated DNA binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007549	dosage compensation
GO:0016568	chromatin modification
GO:0033128	negative regulation of histone phosphorylation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1902750	negative regulation of cell cycle G2/M phase transition

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0000793	condensed chromosome
GO:0001740	Barr body
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005813	centrosome
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome