InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptges

Summary

InnateDB Gene

IDBG-157032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptges

Gene Name

prostaglandin E synthase

Synonyms

2410099E23Rik; D2Ertd369e; mPGES; mPGES-1; Pges

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050737

Encoded Proteins

IDBP-157034

prostaglandin E synthase

IDBP-157036

prostaglandin E synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21497116

Ptges (prostaglandin E2) is produced by LPS-primed macrophages upon treatment with silica crystal and aluminum salts, and is important for the production of IgE in Th2 cells.

PMID 24726877

Influenza A virus infection targets the Ptges and prostaglandin E2 pathway to evade host type I IFN-dependent antiviral immunity

InnateDB Annotation from Orthologs

Summary

PMID 21497116

[Homo sapiens] PTGES (prostaglandin E2) is produced by LPS-primed macrophages upon treatment with silica crystal and aluminum salts, and is important for the production of IgE in Th2 cells. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148344:
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:30889471-30929863

Strand

Reverse strand

Band

Transcripts

ENSMUST00000056046	ENSMUSP00000054679
ENSMUST00000102852	ENSMUSP00000099916
ENSMUST00000132244
ENSMUST00000126588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004667	prostaglandin-D synthase activity
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006693	prostaglandin metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014070	response to organic cyclic compound
GO:0032496	response to lipopolysaccharide
GO:0032526	response to retinoic acid
GO:0034097	response to cytokine
GO:0045087	innate immune response (InnateDB)
GO:0051592	response to calcium ion

Cellular Component

GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm