InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hyou1

Summary

InnateDB Gene

IDBG-157064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hyou1

Gene Name

hypoxia up-regulated 1

Synonyms

AI415631; Cab140; CBP-140; Grp170; Orp150

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032115

Encoded Proteins

IDBP-157066

hypoxia up-regulated 1

IDBP-534749

hypoxia up-regulated 1

IDBP-532896

hypoxia up-regulated 1

IDBP-533199

hypoxia up-regulated 1

IDBP-536537

hypoxia up-regulated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149428:
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq, Oct 2008]
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5\' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44379490-44392369

Strand

Forward strand

Band

A5.2

Transcripts

ENSMUST00000066601	ENSMUSP00000068594
ENSMUST00000162560	ENSMUSP00000123749
ENSMUST00000161537
ENSMUST00000161318	ENSMUSP00000123700
ENSMUST00000160112
ENSMUST00000160902	ENSMUSP00000125594
ENSMUST00000159473	ENSMUSP00000124177
ENSMUST00000161147

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.