InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: F8

Summary

InnateDB Gene

IDBG-157124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor VIII

Synonyms

Cf-8; Cf8; FVIII

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031196

Encoded Proteins

IDBP-157126

coagulation factor VIII

IDBP-252499

coagulation factor VIII

IDBP-542818

coagulation factor VIII

IDBP-542817

coagulation factor VIII

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185010:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:75172715-75382615

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000033539	ENSMUSP00000033539
ENSMUST00000114085	ENSMUSP00000109719
ENSMUST00000147349	ENSMUSP00000114207
ENSMUST00000151772	ENSMUSP00000117919

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006508	proteolysis
GO:0006953	acute-phase response
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0030168	platelet activation
GO:0055114	oxidation-reduction process