InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tor1a

Summary

InnateDB Gene

IDBG-157164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tor1a

Gene Name

torsin family 1, member A (torsin A)

Synonyms

DQ2; Dyt1; torsinA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026849

Encoded Proteins

IDBP-157168

torsin family 1, member A (torsin A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136827:
The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:30960627-30967933

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028200	ENSMUSP00000028200
ENSMUST00000137694
ENSMUST00000144152
ENSMUST00000123762
ENSMUST00000143199

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008092	cytoskeletal protein binding
GO:0016887	ATPase activity
GO:0019894	kinesin binding
GO:0051787	misfolded protein binding

Biological Process

GO:0000338	protein deneddylation
GO:0006200	ATP catabolic process
GO:0006979	response to oxidative stress
GO:0006996	organelle organization
GO:0006998	nuclear envelope organization
GO:0007155	cell adhesion
GO:0031175	neuron projection development
GO:0034504	protein localization to nucleus
GO:0044319	wound healing, spreading of cells
GO:0045104	intermediate filament cytoskeleton organization
GO:0048489	synaptic vesicle transport
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051260	protein homooligomerization
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0061077	chaperone-mediated protein folding
GO:0071712	ER-associated misfolded protein catabolic process
GO:0071763	nuclear membrane organization
GO:0072321	chaperone-mediated protein transport
GO:1900244	positive regulation of synaptic vesicle endocytosis
GO:2000008	regulation of protein localization to cell surface

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005856	cytoskeleton
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030054	cell junction
GO:0030133	transport vesicle
GO:0030141	secretory granule
GO:0030426	growth cone
GO:0030659	cytoplasmic vesicle membrane
GO:0031965	nuclear membrane
GO:0042406	extrinsic component of endoplasmic reticulum membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136827

View Gene Order

ENSBTAG00000020305

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_144884

OMIM

CCDS

CCDS15891

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas