InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp20

Summary

InnateDB Gene

IDBG-157301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp20

Gene Name

ubiquitin specific peptidase 20

Synonyms

1700055M05Rik; AI467231; Vdu2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026854

Encoded Proteins

IDBP-157303

ubiquitin specific peptidase 20

IDBP-157305

ubiquitin specific peptidase 20

IDBP-536296

ubiquitin specific peptidase 20

IDBP-539818

ubiquitin specific peptidase 20

IDBP-541371

ubiquitin specific peptidase 20

IDBP-533227

ubiquitin specific peptidase 20

IDBP-538638

ubiquitin specific peptidase 20

IDBP-625096

ubiquitin specific peptidase 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136878:
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:30982279-31023586

Strand

Forward strand

Band

Transcripts

ENSMUST00000102849	ENSMUSP00000099913
ENSMUST00000061544	ENSMUSP00000060167
ENSMUST00000138161	ENSMUSP00000116696
ENSMUST00000142232	ENSMUSP00000115347
ENSMUST00000125601	ENSMUSP00000121699
ENSMUST00000128295	ENSMUSP00000115613
ENSMUST00000154351
ENSMUST00000136588	ENSMUSP00000119197
ENSMUST00000154634
ENSMUST00000127776
ENSMUST00000170476	ENSMUSP00000127388

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006897	endocytosis
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005813	centrosome
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136878

View Gene Order

ENSBTAG00000020311

Not yet available

Cross-References

SwissProt

TrEMBL

A2AQ34 A2AQ35

UniProt Splice Variant

Entrez Gene

74270

UniGene

Mm.346654

RefSeq

NM_028846 XM_006498392 XM_006498393

OMIM

CCDS

CCDS15893

HPRD

IMGT

MGI ID

MGI:1921520

MGI Symbol

Usp20

EMBL

AL844546

GenPept

RNA Seq Atlas

74270