InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgef11

Summary

InnateDB Gene

IDBG-157390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef11

Gene Name

Rho guanine nucleotide exchange factor (GEF) 11

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041977

Encoded Proteins

IDBP-157394

Rho guanine nucleotide exchange factor (GEF) 11

IDBP-542270

Rho guanine nucleotide exchange factor (GEF) 11

IDBP-531820

Rho guanine nucleotide exchange factor (GEF) 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132694:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:87617559-87738034

Strand

Forward strand

Band

Transcripts

ENSMUST00000039476	ENSMUSP00000039900
ENSMUST00000136072
ENSMUST00000129113	ENSMUSP00000118123
ENSMUST00000142799
ENSMUST00000152006	ENSMUSP00000122166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated