InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tgfbi

Summary

InnateDB Gene

IDBG-157426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgfbi

Gene Name

transforming growth factor, beta induced

Synonyms

68kDa; AI181842; AI747162; Beta-ig; big-h3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035493

Encoded Proteins

IDBP-157428

transforming growth factor, beta induced

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120708:
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:56609603-56639339

Strand

Forward strand

Band

Transcripts

ENSMUST00000045173

ENSMUSP00000037719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001525	angiogenesis
GO:0002062	chondrocyte differentiation
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005802	trans-Golgi network
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000120708

View Gene Order

ENSBTAG00000009513

Not yet available

Pathways

NETPATH

REACTOME

REACT_189085

Disease pathway

REACT_198563

Amyloids pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75925

Amyloids pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

integrin1_pathway

Beta1 integrin cell surface interactions

integrin2_pathway

Beta2 integrin cell surface interactions

integrin3_pathway

Beta3 integrin cell surface interactions

Cross-References

SwissProt

P82198

TrEMBL

A1L353 Q19PV3 Q3TDZ5

UniProt Splice Variant

Entrez Gene

21810

UniGene

Mm.14455

RefSeq

NM_009369

OMIM

CCDS

CCDS36680

HPRD

IMGT

MGI ID

MGI:99959

MGI Symbol

Tgfbi

EMBL

AK084431 AK142323 AK151680 AK152365 AK155572 AK155828 AK169912 AK170495 BC129900 CH466546 DQ512871 DQ512872 L19932

GenPept

AAC37658 AAI29901 ABF72418 ABF72419 BAC39181 BAE25032 BAE30605 BAE31155 BAE33330 BAE33452 BAE41453 BAE41834 EDL41243

RNA Seq Atlas

21810