InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pls3

Summary

InnateDB Gene

IDBG-157531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pls3

Gene Name

plastin 3 (T-isoform)

Synonyms

AI115446; AL024105; T-fimbrin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016382

Encoded Proteins

IDBP-157533

plastin 3 (T-isoform)

IDBP-252550

plastin 3 (T-isoform)

IDBP-252552

plastin 3 (T-isoform)

IDBP-252554

plastin 3 (T-isoform)

IDBP-542045

plastin 3 (T-isoform)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102024:
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83%% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:75785654-75875182

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000033547	ENSMUSP00000033547
ENSMUST00000114059	ENSMUSP00000109693
ENSMUST00000114058	ENSMUSP00000109692
ENSMUST00000114057	ENSMUSP00000109691
ENSMUST00000137192	ENSMUSP00000118995
ENSMUST00000126599

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0060348

bone development

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000102024

View Gene Order

ENSBTAG00000011613

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28777 Mm.396887

RefSeq

NM_001166453 NM_001166454 NM_145629 XM_006527731 XM_006527732 XM_006527733 XM_006527734 XM_006527735

OMIM

CCDS

CCDS30243

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas