Version 5.4
| Mus musculus Gene: Kpna1 | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-157603.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Kpna1 | ||||||||||||||||||||||
| Gene Name | karyopherin (importin) alpha 1 | ||||||||||||||||||||||
| Synonyms | AW494490; IPOA5; mSRP1; NPI1; Rch2 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000022905 | ||||||||||||||||||||||
| Encoded Proteins |
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
karyopherin (importin) alpha 1
|
||||||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] KPNA1 (IPOA5) regulates the import of STAT proteins into the nucleus through nuclear pores.
[Homo sapiens] KPNA1 contains a nuclear localization signal binding site for STAT1 homodimers, STAT1-STAT2 heterodimers and influenza A virus nucleoprotein.
|
||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114030:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 16:35978750-36037131 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | B3 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Apoptosis pathway
Apoptosis induced DNA fragmentation pathway
Activation of DNA fragmentation factor pathway
Apoptotic execution phase pathway
|
||||||||||||||||||||||
| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
ISG15 antiviral mechanism pathway
Activation of DNA fragmentation factor pathway
Apoptotic execution phase pathway
Vpr-mediated nuclear import of PICs pathway
Transport of Ribonucleoproteins into the Host Nucleus pathway
Integration of provirus pathway
Early Phase of HIV Life Cycle pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Apoptosis induced DNA fragmentation pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Apoptosis pathway
Interferon Signaling pathway
Immune System pathway
HIV Life Cycle pathway
HIV Infection pathway
Influenza Life Cycle pathway
Host Interactions of HIV factors pathway
Disease pathway
Apoptosis induced DNA fragmentation pathway
Activation of DNA fragmentation factor pathway
Apoptotic execution phase pathway
Apoptosis pathway
|
||||||||||||||||||||||
| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI |
Class I PI3K signaling events mediated by Akt
|
||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | Q60960 | ||||||||||||||||||||||
| TrEMBL | G3UWJ8 G3UXT6 G3UXW7 G3UYD2 G3UZK5 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 16646 | ||||||||||||||||||||||
| UniGene | Mm.400375 Mm.418279 Mm.421475 Mm.6952 | ||||||||||||||||||||||
| RefSeq | NM_008465 XM_006521814 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS28144 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:103560 | ||||||||||||||||||||||
| MGI Symbol | Kpna1 | ||||||||||||||||||||||
| EMBL | AC133464 AK028259 AK028307 AK154800 AK169311 AK169348 BC006771 CT573031 U20619 U34228 | ||||||||||||||||||||||
| GenPept | AAC52450 AAH06771 BAC25847 BAC25872 BAE32838 BAE41066 BAE41098 | ||||||||||||||||||||||
| RNA Seq Atlas | 16646 | ||||||||||||||||||||||